Research project plan

Research project plan

OMEC-1: Systematic review

  • Focus on oligometastatic esophagogastric cancer
  • Outline current evidence on (‘Topics’):
    • Definition: how many lesions / organs
    • Location: esophageal vs. gastro-esophageal junction vs. gastric cancer
    • Time aspect: synchronous vs. metachronous vs. recurrence
    • Patient selection
    • Treatment goals: cure vs. postpone systemic treatment
    • Treatment options: systemic vs. local vs. multimodal
    • Treatment outcomes: survival / toxicity / Quality of Life
    • (Re-)staging, timing and tools
    • Conversion surgery
    • Classification of (oligo)metastatic disease (Yoshida/modified GIRCG)
  • Systematic identification of existing (lack of) evidence and (lack of) consensus per issue.

Article link

OMEC-2: Distribution of real-life cases

  • Distribution of 15 real-life clinical cases of esophageal and gastric cancer, provided by UMC Utrecht and Amsterdam UMC, across OMEC-European experts and the OMEC-board member peers
  • Asking for local MDT responses on whether the case is considered oligometastatic and what the proposed treatment should be.
  • All selected patients are in good clinical condition, with no comorbidities, were FDG-PET-staged and have ≤5 metastases.
  • Evaluation and reporting of varying opinions will be performed as a ground for discussion and content of Delphi rounds (OMEC-3).

Article link

OMEC-3: Delphi consensus rounds

  • Delphi consensus rounds through 2 online survey Delphi rounds and a consensus meeting, resulting in a consensus statement.
  • Article link


  • The systematic review and consensus reached in OMEC 1-3 will lead to publication of a European multidisciplinary consensus statement and recommendations on the decision-making process for oligometastatic esophagogastric cancer.


  • The multidisciplinary consensus statement and recommendations on the decision-making process in OMEC-4 will lead to a prospective multidisciplinary prospective registration study.